Atopic eczema is a complex, multi-factor disease in which the skin barrier function plays a crucial role.
Little water evaporation, so the allergens cannot get through.
Anormally permeable skin
The epidermis is abnormal and does not play its "barrier" role. The skin lets too much water evaporate : the skin is dry.
It lets allergens in more easily, which may trigger an inflammatory reaction (eczema flare-ups).
The skin does not play its protective role.
From the Information for Parents DVD. All of the Foundation's support materials and documents
An excessive reaction to allergens
Even very small quantities of allergens trigger ecessive reactions from the immune system.
In particular, a category of T lymphocytes, which manufacture lgE, develops.