Lexicon for Atopic Dermatitis

This is a lexicon for Atopic Dermatitis.
Click on a letter and discover all the related terms and their definition.

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  • Lactobacilla

     

    Bacteria that make up part of the intestinal flora; they are non-pathogenic. 
    Several studies have investigated the efficacy of lactobacilla and other probiotics (bacteria that are beneficial to health) in preventing and treating atopic dermatitis. They gave mixed results, which are currently hard to interpret. Nonetheless, administering probiotics (such as yoghurts or food supplements) must not be relied upon to improve atopic dermatitis. 
     
  • Langerhans (cells)

     

    Epidermal cells discovered in the 19th century by Paul Langerhans, who was only a medical student at the time. They are dendritic cells (with a star shape) that play a role in triggering immune responses, particularly in contact allergies.
     
  • Lanolin

     

    A complex lipid obtained from sheep's wool, commonly used in cosmetics for its hydrating properties.
     
  • Latex

     

    A complex substance taken from the rubber tree. Latex is elastic and is manufactured from rubber. Latex can trigger allergic reactions.
     
  • Leiner-Moussous (disease)

     

    Another term for infantile seborrheic dermatitis (see this term). Moussous was a pediatrician from Bordeaux, Leiner a German pediatrician.
     
     
  • LEKTI

     

    LEKTI inhibits proteases, which are enzymes that break down proteins. The balance between proteases and their inhibitors plays an important role in atopic dermatitis and related conditions, such as Netherton syndrome, which is caused by a genetic deficiency in the molecule known as LEKTI, an anti-protease. Because of this deficiency, proteases are hyperactive and degrade important proteins for epidermal function. The result is anomalies in the skin: an ichthyosis-like state, and inflammation
     
  • Leukotrienes

     

    Lipidic molecules, similar to prostaglandins, which are involved in inflammation, particularly in the skin.
     
  • Lichenification

    Thickening of the skin

  • Lichenification

     

    Thickening of the skin caused by scratching. This is often seen in chronic eczema, and above all in atopic dermatitis, as well as chronic itching conditions caused by nervous issues. 
     
  • Local corticosteroid therapy

     

    Application of corticosteroids in the form of a cream (or ointment or gel). 
    Local corticosteroid therapy was discovered in 1952 and was a real breakthrough in treatment for eczema, particularly atopic dermatitis. It is the most effective treatment for these conditions. Of course, in order to benefit from its advantages and avoid its disadvantages, patients must adhere to the usage instructions.
    There are around thirty different corticosteroids. They are classified according to their anti-inflammatory effect, and the most powerful (effective) are the most likely to cause side effects if used for a prolonged period.  
    In practice, moderate corticosteroids (for example, desonide) and powerful ones (such as a betamethasone derivative) are used in small quantities in gradually decreasing amounts: every day for a few days, then two days per week, then once a week for a longer period. 
    The quantities used should be moderate and checked by a doctor.
    In practice, local corticosteroid therapy requires detailed and properly understood instructions to be given so that patients are able to use it confidently, effectively and safely. This is one of the goals of therapeutic education.
     
  • Loricrin

     

    Loricrin is one of the important proteins that make up the cornified envelope that surrounds corneocytes. It therefore plays a role in epidermal solidity and the barrier function.
     
  • Lotion

     

    A type of cosmetic emulsion with a liquid consistency. The term 'solution' is more or less a synonym.
     
  • Lymphocytes

     

    A type of white blood cell. Lymphocytes are the major cells involved in the immune system and are involved in: defense against infections, allergies, and all other functions of the immune system.  
     
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