Lexicon for Atopic Dermatitis

This is a lexicon for Atopic Dermatitis.
Click on a letter and discover all the related terms and their definition.

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  • Netherton syndrome

     

    A genetic condition that combines three symptoms: a certain kind of ichthyosis, which begins as erythroderma (see this term), and then takes on a curious appearance, with desquamation, and anomalies in the structure of the hair (bamboo hair), alongside eczema very similar to that of atopic dermatitis, which can be severe. Netherton syndrome is caused by a mutation in the spink5 gene, which encodes proteases known as LEKTI (see this term). Thus uninhibited, epidermal proteases are activated and destroy many proteins, including filaggrin. A similar excess in proteases has been observed in atopic dermatitis. 
     
  • Neurodermatitis

     

    An old dermatological term used to describe thickening of the skin and a lined appearance, caused by scratching and with no other cause (i.e. without eczema). There is some confusion surrounding the usage of this term, due to the fact that some came to believe that atopic dermatitis was a nervous or even psychiatric condition. 
     
  • Neuromediators

     

    Molecules involved in the transmission of information between nerve fibers, and between nerve fibers and other cells, such as epidermal cells. Disorders in neuromediators are associated with pruritus and scratching
     
  • Neuropeptides

     

    Neuropeptides are small proteins (several amino acids) secreted by nerve cells, that act on the surrounding cells and tissues to transmit nerve signals. There are many neuropeptides and some of them are involved in triggering itching, which is important in atopic dermatitis
     
  • Nickel

     

    A metal found in most costume jewelry (any not made of pure gold). Nickel is the most common allergen responsible for allergic contact eczema. Atopy patients, who have fragile skin, should therefore avoid unnecessary contact with allergizing substances. For example, young girls should not have their ears pierced.
     
  • NMF

     

    Natural Moisturizing Factor. This term describes substances that are responsible for hydration of cells in the stratum corneum. The main components of NMF are hyaluronic acid, urea, and amino acids. Many of these are the result of the degradation of filaggrin, which is normally found in the stratum corneum. 
     
  • Nummular eczema

     

    Eczema presenting with well-defined rounded plaques, which appear like coins.
     
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