Moisturizers continue to be an important adjunct therapy for a variety of dermatologic conditions.
As we learn more about skin barrier function and mechanisms leading to barrier dysfunction, new technologies lead the way in our search for the perfect moisturizer.
Bleomycin hydrolase downregulation in lesional skin of adult atopic dermatitis patients is independent of FLG gene mutationsVie, 03/04/2015 - 19:32
Atopic dermatitis (AD) pathogenesis is still incompletely understood. The major genetic risk factor is nonsense mutations of the FLG gene encoding filaggrin. 1 Filaggrin is a key protein for the stratum corneum (SC) barrier functions. 2,3 It is synthesized as a 400 kDa precursor named profilaggrin.
C. Méni, C. Bodemer, A. Toulon, S. Merhand, N. Perez-Cullell, S. Branchoux, C. Taieb
The Leuven Itch Scale (LIS). The LIS is an instrument to measure itch in patients experiencing pruritus of different origin. The novelty of the LIS, in contrast with several previously developed instruments, is that it approaches itch as a symptom, and that it consequently measures all aspects of that symptom: frequency, duration, severity, circumstances, treatment, consequences, sensory characteristics, distress and location(s).
Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte DifferentiationVie, 03/04/2015 - 17:58
Valérie Pendaries, Jeremy Malaisse, Laurence Pellerin, Marina Le Lamer, Rachida Nachat, Sanja Kezic, Anne-Marie Schmitt, Carle Paul, Yves Poumay, Guy Serre and Michel Simon
Atopic dermatitis or eczema is a condition that specialists consider mild, but which gives rise to so many different interpretations, prohibitions, excesses, consultations and conflicting opinions that, in recent years, necessary centers have been set up for listening to patients and providing advice and information in France.
«Elementos de formación complementarios para su actividad». La Fundación Eczema le invita a descubrir o redescubrir las conferencias de los 3os Encuentros Internacionales sobre la Educación Terapéutica en la dermatitis atópica...
TOPICOP©: A New Scale Evaluating Topical Corticosteroid Phobia among Atopic Dermatitis Outpatients and Their ParentsMar, 05/08/2014 - 14:49
The fear of using topical corticosteroids, usually called topical corticophobia, is a frequent concern for atopic dermatitis patients and/or their parents. Assessing patients’ atopic dermatitis and their parents’ topical corticosteroid phobia is an essential step to improving adherence to treatment. Because topical corticophobia appears to be a complex phenomenon, its evaluation by binary responses (yes/no) is too simplistic. Thus, a scale is needed, which is capable of identifying the subtleties of topical corticosteroid phobia.
By Dr. Daniel Wallach
Atopic dermatitis is a complex illness that is closely related to two other conditions, allergic asthma and allergic rhinoconjunctivitis. The common factor between these three illnesses, which we call the atopic predisposition, is a predisposition to produce IgE-class antibodies directed against antigens present in the everyday environment. Therefore, a child with atopic dermatitis (eczema in early childhood) is more at risk than another child of going on to develop allergic rhinoconjunctivitis and asthma.